2019 NFL Week 6 Best Odds and Matchups

1. San Francisco 49ers at Los Angeles Rams (Sunday, 4:05 PM ET, FOX)

The Rams (3-2 SU, 4-1 ATS) are reeling after back-to-back losses, and they won’t have LB Clay Matthews for the next month because of a broken jaw. But Los Angeles do have the rest advantage in this NFC West battle. They fell 30-29 to the Seattle Seahawks last Thursday as 1.5-point road dogs on the NFL odds board; at press time, LA are laying 3.5 points to the visiting Niners (4-0 SU, 3-1 ATS).

2. Detroit Lions at Green Bay Packers (Monday, 8:15 PM ET, ESPN)

For a change, Monday Night Football has the best night game on the Week 6 slate. The Packers (4-1 SU and ATS) continue to win, and despite appearances, their offense has been quite balanced between running and passing under new head coach Matt LaFleur. The NFL lines have Green Bay favored by four points over the Lions (2-1-1 SU, 3-1 ATS), who took the bye last week.

3. Carolina Panthers vs. Tampa Bay Buccaneers (Sunday, 9:30 AM ET, NFL)

Tottenham Hotspur Stadium in London will be the host venue for this all-NFC South affair between the Panthers (3-2 SU and ATS) and Buccaneers (2-3 SU and ATS). This new stadium has a retractable roof, so the 47.5-point total won’t be affected by the weather. The Panthers are 2-point “road” favorites, even though QB Cam Newton (foot) won’t be playing.

4. Houston Texans at Kansas City Chiefs (Sunday, 1 PM ET, CBS)

This game features the highest total for the odds on NFL Sunday at 55 points, although the Chiefs (4-1 SU, 3-2 ATS) might have a little less zip with QB Patrick Mahomes tweaking his ankle against Indianapolis. The Texans (3-2 SU and ATS) have moved from +8 to +4.5 since the open.

5. New Orleans Saints at Jacksonville Jaguars (Sunday, 1 PM ET, CBS)

Two of the league’s better back-up quarterbacks will be on display when Teddy Bridgewater and the Saints (4-1 SU, 3-2 ATS) visit Gardner Minshew and the Jaguars (2-3 SU, 3-2 ATS). The Jags are 1-point favorites with a total of 44.5.

6. Seattle Seahawks at Cleveland Browns (Sunday, 1 PM ET, FOX)

All of those fans who bet on the NFL and the Browns (2-3 SU and ATS) have been disappointed thus far. QB Baker Mayfield has been out-performed by just about everyone, including Russell Wilson, who’s played like an MVP for the Seahawks (4-1 SU, 2-3 ATS). They’re 2-point road favorites in this contest.

7. Philadelphia Eagles at Minnesota Vikings (Sunday, 1 PM ET, FOX)

The Eagles (3-2 SU, 2-3 ATS) and Vikings (3-2 SU and ATS) are both defensively sound, but Philly’s offense and special teams give them the edge in this matchup as 3-point road dogs.

8. New York Giants at New England Patriots (Thursday, 8:20 PM ET, FOX)

They can’t all be gems. The Patriots (5-0 SU, 3-2 ATS) provide all the starpower in this contest, as they continue their march through an incredibly soft schedule against the Giants (2-3 SU and ATS), who are getting 17 points in Foxborough.

9. Dallas Cowboys at New York Jets (Sunday, 4:25 PM ET, CBS)

QB Sam Darnold will likely make his return for the Jets (0-4 SU, 1-3 ATS) on Sunday, which is important enough to keep their game against the Cowboys (3-2 SU and ATS) circled for now. Dallas has dropped two straight after starting the season undefeated.

10. Pittsburgh Steelers at Los Angeles Chargers (Sunday, 8:20 PM ET, NBC)

Finally, we have this week’s episode of Sunday Night Football, where the Steelers (1-4 SU, 3-2 ATS) should be down to third-string QB Devlin Hodges after Mason Rudolph was placed in concussion protocol. They’re getting seven points against the Chargers (2-3 SU, 1-3-1 ATS).