Since 1904, the Oklahoma Sooners and the rival Oklahoma State Cowboys have met each other on the football field in what’s become known as the Bedlam Game. The No. 5 Sooners (7-1 SU, 4-4 ATS) have the overall advantage at 86-18-7, but this Saturday, they’re 3-point road dogs against the No. 11 Cowboys (7-1 SU, 5-3 ATS) in Stillwater. Kick-off is at 4 PM ET on FS1. It’s a battle of two Heisman Trophy candidates: Oklahoma quarterback Baker Mayfield, available at +800 on the NCAAF props market, and Oklahoma State quarterback Mason Rudolph at +3300.

That’s not the only Top-25 matchup on the Week 10 college football odds board. Here are some of the other key games on Saturday’s NCAAF betting slate, all times Eastern:
 

No. 7 Penn State Nittany Lions at No. 24 Michigan State Spartans (noon, FOX)

Penn State (7-1 SU, 6-1-1 ATS) coughed up that big Week 9 game against Ohio State, but they still beat the spread, and they can stay in the College Football Playoff picture with a win over the Spartans (6-2 SU, 5-3 ATS). The Nittany Lions are 9.5-point favorites at press time after opening at –7.5.

 

No. 4 Clemson Tigers at No. 20 NC State Wolfpack (3:30 PM, ABC)

The defending National Champions from Clemson (7-1 SU, 4-3-1 ATS) are back in a CFP spot, although a loss to North Carolina State (6-2 SU, 3-5 ATS) as 7.5-point road favorites would pretty much seal the ACC Atlantic Division for the Wolfpack. 

 

No. 19 LSU Tigers at No. 2 Alabama Crimson Tide (8 PM, CBS)

Alabama (8-0 SU, 4-4 ATS) should be fired up after the CFP rankings came out with Georgia in the No. 1 spot. They’re laying 21 points to LSU (6-2 SU, 3-4-1 ATS), who have suddenly come to life with back-to-back wins straight up and against the spread.

 

No. 13 Virginia Tech Hokies at No. 10 Miami Hurricanes (8 PM, ABC)

This could be the best matchup on the Week 10 NCAAF odds board. The Hurricanes (7-0 SU, 3-4 ATS) have played slightly better football this year, but with quarterback Malik Rosier nursing a sore shoulder, Virginia Tech (7-1 SU, 5-3 ATS) is a 3-point road favorite at press time.

 

*Odds as November 3, 2017