It’s been the NFL’s flagship program since it was born in 2006, but this year, Sunday Night Football hasn’t delivered the kind of high-octane matchups we’re used to – until now. The must-see game on the NFL betting odds list for Week 4 will be at the Superdome, and it features the league’s best offense (thus far) taking on one of the worst defenses you’ll find anywhere. Here are the top 10 games to look for this week at Bovada Sportsbook.

2019 NFL Week 4 Best Odds and Matchups

1. Dallas Cowboys at New Orleans Saints (Sunday, 8:20 PM ET, NBC)

Everything is coming along nicely for the Cowboys (3-0 SU and ATS), one of four teams to start the year with a perfect record against the spread on the NFL odds board. The combination of QB Dak Prescott and RB Ezekiel Elliott is running smoothly behind arguably the best offensive line in the NFL. The Saints (2-1 SU, 1-2 ATS), on the other hand, are in a bit of trouble with QB Teddy Bridgewater stepping in for the injured Drew Brees. They don’t have a lot of stopping power on defense, and they’re 3-point home dogs for this game, with a total of 47.

2. Philadelphia Eagles at Green Bay Packers (Thursday, 5:20 PM ET, FOX)

The Packers are also perfect through three games – or at least they have a perfect record. Their offense is still very much a work in progress under rookie head coach Matt LaFleur, but they should be able to beat the Eagles (1-2 SU, 0-3 ATS), who haven’t played very good defense this year, leaving them and the horrible Miami Dolphins as the only 0-3 ATS teams on the NFL lines heading into Week 4. Green Bay are 5-point favorites at press time with a 46-point total.

3. Minnesota Vikings at Chicago Bears (Sunday, 4:25 PM ET, CBS)

The odds on NFL Sunday have the Chicago Bears (2-1 SU, 1-2 ATS) laying two points to the Minnesota Vikings (2-1 SU and ATS) in this all-NFC North matchup at Soldier Field – which has the lowest total on the board at 38.5 points. Not a surprise given the defensive quality of both teams and the rainy conditions forecast for Chicago. 

4. New England Patriots at Buffalo Bills (Sunday, 1 PM ET, CBS)

These AFC East teams share the same record at 3-0 SU and 2-1 ATS, but New England have played at a much higher level thus far. They’re 7.5-point road favorites despite letting WR Antonio Brown go free after just one game as a Patriot.

5. Cleveland Browns at Baltimore Ravens (Sunday, 1 PM ET, CBS)

The AFC North heats up when the Browns (1-2 SU and ATS) visit the team that used to bear their name. The Ravens (2-1 SU, 1-2 ATS) are laying seven points at home against Cleveland’s stuck-in-the-mud offense.

6. Seattle Seahawks at Arizona Cardinals (Sunday, 4:05 PM ET, FOX)

Kyler Murray takes another crack at his first NFL win this Sunday, but his Cardinals (0-2-1 SU, 2-1 ATS) are 5.5-point home dogs against the Seahawks (2-1 SU, 1-2 ATS), who have excelled on offense this year. 

7. Kansas City Chiefs at Detroit Lions (Sunday, 1 PM ET, FOX)

Pat Mahomes always makes it fun to bet on the NFL, even if Kansas City (3-0 SU and ATS) will have to deal with the ho-hum Lions (2-0-1 SU, 2-1 ATS) and their quality defense. The Chiefs have a decent shot to cover as 7-point favorites; however, that 54-point total might be hard to reach.

8. Cincinnati Bengals at Pittsburgh Steelers (Monday, 8:15 PM ET, ESPN)

Mason Rudolph gets another start at quarterback for the Steelers (0-3 SU, 1-2 ATS) as they prepare to host Andy Dalton and the Bengals (0-3 SU, 2-1 ATS) on Monday Night Football. Pittsburgh can get off the schneid here as 4-point home favorites.

9. Carolina Panthers at Houston Texans (Sunday, 1 PM ET, FOX)

QB Kyle Allen looked pretty good for the Panthers (1-2 SU and ATS) last week in place of Cam Newton, who could miss the whole season with a Lisfranc injury. The Texans (2-1 SU and ATS) will test Allen as 4.5-point favorites.

10. Jacksonville Jaguars at Denver Broncos (Sunday, 4:25 PM ET, CBS)

The Gardner Minshew Experience lands at Mile High this Sunday when the Jaguars (1-2 SU, 2-1 ATS) visit the Broncos (0-3 SU, 1-2 ATS), who are getting mixed results from veteran QB Joe Flacco. Jacksonville have legs as 3-point road dogs with a low total of 39.

For more info on how to place a bet for your NFL Sunday party. Head over to our Bovada NFL Betting Guide for ways to bet on singles, props and futures for real cash!

*Odds as of September 25, 2019